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Journal of Research in Medical Education & Ethics
Year : 2011, Volume : 1, Issue : 3
First page : ( 149) Last page : ( 152)
Print ISSN : 2231-671X. Online ISSN : 2231-6728.
Article DOI : 10.5958/p2231-671X-1211-1-3-33

Beta (β) Blockers: A Novel Approach to Fight Malaria

Nandha Ruchika1,*, Singh Harpal2, Garg Kamlesh3

1Department of Pharmacology, Dr HSJ Institute of Dental Sciences, Panjab University, Chandigarh

2Department of Critical Care, Fortis Hospital, Mohali

3Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi

*Email: rnandha23@yahoo.co.in

Online published on 29 December, 2011.

Received:  26  July,  2011; Accepted:  19  October,  2011.

Abstract

Malaria is one of the extensively prevalent parasitic diseases and kills more than a million people a year despite the availability of a wide range of antimalarial drugs. Traditional antimalarial drugs act on the parasite itself. Due to rapid mutations and multiplication, the parasite has become resistant to conventional antimalarial drugs very rapidly. Knowing the fact that disease has become non respondent to most of classical antimalarial drugs, new drugs are urgently needed. Recent research has shown potential anti-malarial effect of β blockers. Propranolol has been studied in this regard which acts by blocking the erythrocyte guanine nucleotide regulatory G protein stopping both parasitic invasion & proliferation inside the erythrocyte without developing resistance. β blocker/antimalarial combination therapy is currently in the preclinical phase but with more exploratory human trials it can provide a new hope for millions of patients who are not responding to conventional treatments.

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Keywords

Malaria, Antimalarial drugs, Propranolol.

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