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Journal of PEARLDENT
Year : 2014, Volume : 5, Issue : 4
First page : ( 1) Last page : ( 9)
Print ISSN : 0976-0180. Online ISSN : 2229-4457.
Article DOI : 10.5958/2229-4457.2014.00009.9

Cell signalling molecules

Dr. Kaur Gurpreet1,*, Dr. Shetty Prasad B2, Dr. Mohiuddin Khizer3, Dr. Grover Deepak1

1Reader, Dept. Of Periodontics & Oral Implantology, National Dental College & Hospital, Derabassi, Punjab

2Reader, Dept. Of Periodontics & Oral Implantology, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka

3Assisstant Professor, Department of Periodontics & Oral Implantology, Al-Ameen Dental College & Hospital, Bijapur, Karnataka

*Address For Correspondance: Dr. Gurpreet Kaur, Reader, Dept. Of Periodontics & Oral Implantology, National Dental College & Hospital, Derabassi, Punjab

Online published on 17 March, 2015.

Abstract

All periodontal cells are capable of expressing a broad range of gene products, including matrix proteins, proteases involved in tissue remodeling (such as collagenases) and cytokines. Mesenchymal cells in the periodontal connective tissues encounter a complex array of stimuli that include soluble agents (such as polypeptide growth factors, cytokines, neuropeptide and chemotherapeutic agents), insoluble extracellular matrix proteins and other cells. The mechanisms that permit cells to respond to extracellular stimuli are essential for normal growth and function. Characterization of how these pathways are up-regulated or down-regulated in response to other agents may eventually allow the predictability of periodontal regeneration to be enhanced. The current review aims to provide a comprehensive overview to the various cell signaling pathways and molecules that mediate the periodontal disease process and can serve as a target for periodontal therapy.

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Keywords

Cell signaling, Receptors, Ligand, Cytokines.

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