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Journal of Indian Academy of Forensic Medicine
Year : 2010, Volume : 32, Issue : 3
First page : ( 199) Last page : ( 203)
Print ISSN : 0971-0973. Online ISSN : 0974-0848.

Animal study of silicosis in respect of morbidity and mortality

Biswas Supreeti*,#Associate Professor, Mondal Kanchan Kumar**Assistant Professor, Lall S B***Formerly Additional Professor, Batabyal Suddhodhan****Professor & Head, Haldar Swaraj*****Professor & Head

*Deptt. of Pharmacology, R.G. Kar Medical College, Kolkata-700004

**Deptt. of Ophthalmology, R.G. Kar Medical College, Kolkata-700004

***Pharmacology, AIIMS, New Delhi

****Upgraded Deptt. of Forensic & State Medicine, Calcutta Medical College, Kolkata

*****Deptt. of Forensic & State Medicine, R. G. Kar Medical College, Kolkata

#C-4, B-l, Swarnamahal Apartment, 10/1 Mordecai Lane, Chhatakal, Dum Dum- 700074, West Bengal, India, E-mail: supbswsmndl@yahoo.co.in

Abstract

Silica activates release of biochemical substances in lungs. To evaluate duration dependent toxic effects of silica by biochemical changes in Broncho Alveolar Lavage Fluid (BALF) and by post-mortem findings we developed a series of rat silicosis. Based on duration of exposures, single intratracheal injection of quartz dust in saline to acute models (n=3) and inhalation of quartz dust with air to chronic models (n=3) were administered. Control rats received vehicle only. Group wise BALF was collected on completion of exposure periods. Postmortem examination was performed. Protein, hydroxyproline, elastase and Elastase Inhibitory Capacity (EIC) in BALF were measured. Post-mortem examination revealed progressive fibro-nodular changes in lungs. Biochemical parameters excepting EIC in both models showed significant (p< 0.001) gradual rise. Duration dependent biochemical changes in BALF due to silica were found responsible'for progressive morbidity and may be considered as early markers for diagnosis, thereby, preventing increasing morbidity and death.

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Keywords

Silicosis, Post-Mortem Findings, Early Biochemical Markers, BALF.

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