Journal of Ecophysiology & Occupational HealthYear : 2008, Volume : 8, Issue : 1 & 2
First page :
Last page :
ISSN : 0972-4397.
Effect of Tagetes flower extract on renal functions following mercuric chloride exposure
Saxena Prabhu N.1, Singhal Renu1, Saxena Nishi1, Singh D.K.2
1Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra, (U.P.), India.
2Department of Forestry, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra, (U.P.), India.
Effect of oral administration of mercuric chloride at a dose of 0.926 mg/kg b.wt. for 1 day, 0.132 mg/kg b.wt. for 7 days, 0.066 mg/kg b.wt. for 14 days and 0.044 mg/kg b.wt. for 21 days were studied with respect to renal functions in albino rats. These include estimation of serum urea, serum uric acid and serum creatinine. The mitigative role of flower extract of Tagetes erecta (10 mg/kg) was also studied in albino rat under the stress of mercuric chloride. The results revealed an increase in serum urea, uric acid and creatinine in mercuric chloride treated rats per Os. Significant enhancement in the level of serum urea, serum uric acid and serum creatinine are suggestive of decreased glomerular filtration rate (GFR). The observations further depict that rats received 10 mg/kg of flower extract with mercuric chloride had lower serum urea, serum uric acid and serum creatinine compared to mercuric chloride alone. The flower extract of Tagetes erecta treated animals reveal comparatively lesser reduction in their body weight than those treated with mercuric chloride alone. These data suggest that flower extract of Tagetes may protect renal functions which were disturbed by mercuric chloride intoxication.
Mercuric chloride, Flower extract of Tagetes erecta, Biochemical parameters, Serum.