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Journal of Animal Research
Year : 2012, Volume : 2, Issue : 3
First page : ( 199) Last page : ( 207)
Print ISSN : 2249-5290. Online ISSN : 2277-940X.

Immunomodulatory assessment of methanolic extracts of Hippophae rhamnoides, H. salicifolia and Piper longum in comparison to standard Levamisole against migratory behaviour of Toxocara canis larvae in murine model

Moudgil Aman Dev1,*, Mittra S.1, Singla L. D.1, Pallavi2

1Department of Veterinary Parasitology, Dr. G.C. Negi College of Veterinary and Animal Sciences, Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishwavidayalaya, Palampur-176062, Himachal Pradesh, India

2Division of Veterinary Public Health, Indian Veterinary Research Institute, Barielly, Uttar Pradesh, India

*Corresponding Author: Aman Dev Moudgil; Email: moudgil.aman@gmail.com

Abstract

Toxocara canis owns an exceptional ability to withstand host's immune system by encystment of larval stages into host's tissue and thus, paving way for anthelmintic ineffectiveness against the larval stages of the parasite. The aim of the present study was to evaluate the effect of three herbal (methanolic extracts of Hippophae rhamnoides, H. salicifolia and Piper longum) and one allopathic (levamisole) immunomodulators on the migratory behaviour of Toxocara canis larvae in tissues of Swiss albino mice, experimentally infected with T. canis embryonated eggs on day 14 of immunomodulatory medication. Larval migration studies of T. canis by tissue digestion method in various organs of experimentally infected mice, at days 14 and 28 post infection revealed H. salicifolia to be a superior immunomodulator followed by H. rhamnoides, levamisole and P. longum.

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Keywords

Hippophae salicifolia, Hippophae rhamnoides, ImmunomodulatorsLevamisole, Piper longum, Swiss albino mice, Toxocara canis.

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