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Indian Journal of Veterinary Research (The)
Year : 2015, Volume : 24, Issue : 1
First page : ( 1) Last page : ( 7)
Print ISSN : 0971-4251. Online ISSN : 0974-0171.

Pathological and immunological changes in sheep naturally infected with miscellaneous pulmonary nematodes in the Mexican template plateau region

Coyote-Camacho Betsy1, Montes-de-Oca-Jiménez Roberto1,*, López-Arellano María-Eugenia2, Salem Abdelfattah Z.M.1, Cubillos-Godoy Victor3, Fernández-Rosas Pomposo1, Ortega-Santana César1

1Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México

2Centro Nacional de Investigaciones Disciplinarias en Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Carretera Cuernavaca-Cuautla # 8534, Jiutepec, Morelos, México, C.P. 62550

3Facultad de Ciencias Veterinarias, Instituto de Patología Animal, Universidad Austral de Chile, Isla Teja S/N. Casilla 567, Valdivia, Chile

*romojimenez@yahoo.com, Tel/Fax: +52-722-2965548

Online published on 26 October, 2015.


Twenty-one lung parasite infected sheep ranging from 12 to 18 months old were selected. Larvae from feces and adult nematodes from pulmonary tissue sections were collected. Parasitological, histopathological and immunocytochemical techniques were used to identify nematode genera, damaged tissue and immune cells involved in a lungworm infected sheep using a parasite-free group as control. Results showed that 71.4% and 52.4% of Dictyocaulus filaria larvae and adult stages, respectively, and 28.5% and 9.5% of Muellerius capilaris and Protostrongylus spp. larvae respectively. Pulmonary parenchyma showed infection with D. filaria, M. capillaris and Protostrongylus spp larvae. Histopathology studies showed eosinophilia and microgranulomas around calcified nematodes on alveolar tissue, as well as mononuclear cells, fibrous connective tissue and hyperplasia of mucosa layers on bronchial tissue. Moreover, increased numbers of CD4+, gd+ T and B+ cell population were identified on lung lymph tissue, pulmonary parenchyma and mucosa layers of infected sheep. In contrast, a lower amount of CD8+ and macrophages was observed in the same serial tissue sections. Pulmonary damages in naturally infected adult sheep were attributed to the mixed effect of the three genera of lungworm nematodes. The activation of the host immune cell response by the presence of lungworm in the respiratory tract should be analysed to look for possible immunological applications for diagnosis and parasitic control in endemic regions of Mexico.



Immune cells, Lungworms, Pathology, Sheep, CD4+ T cell.


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