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Year : 2014, Volume : 38, Issue : 1
First page : ( 49) Last page : ( 51)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2014 March 1.
Article DOI : 10.5958/0973-970X.2014.01134.1

Pathological changes in induced acute fenvaleratetoxicity in broilers

Shriwas S.K.1, Mondal M.1,*, Ghosh R.C.1, Maity S.K.1, Koley K.M.1

1Department of Veterinary Pathology, College of Veterinary Science and Animal HusbandryIndira Gandhi Agricultural University, Anjora, Durg-491001, Chhattisgarh, India

*Corresponding author: email: drmondalmm@rediffmail.com

Received:  18  November,  2013; Accepted:  18  February,  2014.

Abstract

The present study on acute toxicity of fenvalerate was undertaken to find out its toxic effects and to know the approximate lethal dose (ALD) by oral route in broilers. Initially, different arbitrary doses (300, 450, 675, 1013 and 1519 mg/kg body weight) of fenvalerate were given to broilers of each group till the lowest lethal dose was achieved. The ALD of fenvalerate by oral administration in broilers was determined as 1519 mg/kg body weight. Intoxicated broilers exhibited depression, dullness, anorexia, yellowish diarrhoea, open mouth breathing, incoordination in movement and tremors followed by dyspnoea, tonic convulsion, coma and death. At necropsy, varying degree of congestion in most of the organs and severe haemorrhages in thymus were noticed in treated broilers. Microscopically, treated broilers had lesions suggestive of toxic hepatitis, nephritis and severe lymphocytolysis in the lymphoid organs. There was loss of striation with exudation and mild necrosis in cardiac muscles. Brain revealed congestion and degenerative to necrotic changes.

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Keywords

Acute toxicity, Broilers, Fenvalerate, Pathology.

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