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Indian Journal of Veterinary Pathology
Year : 2011, Volume : 35, Issue : 2
First page : ( 227) Last page : ( 229)
Print ISSN : 0250-4758. Online ISSN : 0973-970X.

Study on immunosuppressive effect of vaccination against infectious bursal disease

Samanta A., Niyogi D.1, Ganguly S.2, Singh Y.D., Pal S., Pradhan S., Patra N.C., Mukhopadhayay S.K.*

Department of Veterinary Pathology, Faculty of Veterinary & Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata-700 037

1Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Narendra Deva University of Agriculture and Technology, Faizabad-224229 (U.P.)

2AICRP on Post Harvest Technology in Department of Fish Processing Technology, Faculty of Veterinary & Animal Sciences, West Bengal University of Animal and Fishery Sciences. Kolkata-700 037

*Corresponding author: email: skmpath@gmail.com

Online published on 20 February, 2012.

Received:  15  June,  2011; Accepted:  20  October,  2011.

Abstract

The study was carried out to describe the effect of two commercially available infectious bursal disease (IBD) intermediate plus vaccines on immune system of broiler chickens having maternal antibody against infectious bursal disease virus (IBDV). IBD vaccines proved to be immunogenic as indicated by ELISA titers on 24th and 38th day of age. However, IBD vaccines induced bursal atrophy as indicated by studies on the ratio between bursal weight and body weight on 19th, 29th and 38th day of age. Histopathological studies of lymphoid organs indicated that the vaccines induced bursal damage after vaccination. Antibody response to vaccination against Newcastle disease (ND) measured at 31st and 38th day of age showed significantly low (p<0.05) ND haemagglutination inhibition antibody titers as compared to birds of control group indicating immunosuppressive effects of both the IBD vaccines on the immune system. From the present study, it was revealed that vaccine against IBD vaccines imposed immunosuppressive effect.

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Keywords

Broiler, infectious bursal disease, vaccine.

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