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Indian Journal of Veterinary Pathology
Year : 2010, Volume : 34, Issue : 2
First page : ( 171) Last page : ( 175)
Print ISSN : 0250-4758. Online ISSN : 0973-970X.

Clinico-pathological and pathomorphological studies on alpha-cypermethrin induced toxicity in rats

Thiyagaseelan C., Mukhopadhayay S.K.*, Ganguly S.1, Pradhan S., Patra N.C., Niyogi D.2

Department of Veterinary Pathology, Faculty of Veterinary & Animal Sciences, Kolkata 700094

1AICRP on Post harvest Technology in Department of Fish Processing Technology, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata 700094

2Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Narendra Deva University of Agriculture and Technology, Faizabad

*Corresponding author; e-mail: skmpath@gmail.com

Received:  5  October,  2010; Accepted:  13  December,  2010.

Abstract

The present study was carried out to study the pathomorphological and hematobiochemical alterations induced by oral administration for alpha-cypermethrin in rats for 28 days. Ten inbred Albino Wistar rats in each group were daily administered with alphacypermethrin at dose rate of 5.83 mg/kg, 7.25 mg/kg, 14.5 mg/kg, respectively, with dimethyl sulfoxide (DMSO) control group. The effect of alpha-cypermethrin was assessed by studying the various parameters viz. clinical, weekly body weight gain, hemato-biochemical and pathomorphological alterations It was observed that alpha-cypermethrin administered at 7.25 mg/kg and 14.50 mg/kg for a period of 28 days induced toxicity symptoms in rats and showed decrease in body weight, sweating on back and spayed hind limbs. Hematological parameters viz. Hb, PCV and TEC revealed significant decrease in treated groups as compared to control. Plasma biochemical parameters viz. ALT, AST and ALP revealed significant increase in all the treated groups. Pathomorphological lesions induced by alpha-cypermethrin toxicity were of vascular, degenerative and necro-biotic in nature and were dose dependant. Liver, kidney and heart were the most affected target organs of alpha-cypermethrin intoxication in rats.

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Keywords

Alpha-cypermethrin, hematobiochemical alterations, pathomorphology, rats.

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