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Indian Journal of Veterinary Pathology
Year : 2004, Volume : 28, Issue : 2
First page : ( 94) Last page : ( 96)
Print ISSN : 0250-4758.

Pathology of liver and other visceral organs of highly productive layer lines infected with subgroup A and C rous sarcoma virus*

Ghosh A.K.1Associate Professor, Pani P.K.2Director (Retired), Chattopadhyay S.K.3Principal Scientist (Retired)

Indian Veterinary Research Institute, Izatnagar-243122

1Department of Genetics and Animal Breeding, College of Veterinary and Animal Sciences, GBPUAT, Pantnagar-263145, U.S.Nagar (UA)

2Central Avian Research Institute, Izatnagar (UP)

3Division of Veterinary Pathology, IVRI, Izatrnagar (UP)

*A part of MVSc thesis submitted to Indian Veterinary Research Institute, Izatnagar (UP)


Pathogenesis of Rous sarcoma virus subgroup A (BS-RSV) and subgroup C [RSV (RAV-49)] infected embryos and chicks of highly productive layer lines (IWJ, IWG and IWC) was studied by inoculating 11-day-old embryos via the chorioallantoic membrane (CAM) route. No pathological changes were observed in liver of fully developed infected prehatching embryos. The histological changes in liver such as engorgement of hepatic blood vessels, degeneration offibroblasts within hepatic lobules, accumulation offibroblasts in liver parenchyma causing compression of hepatic lobules and loss of radiating arrangement of the hepatic cords were first observed in 2-day-old chick. Multiple foci of tumourous growth comprising compact masses of immature fibroblasts resembling fibrosarcomatous changes were detected. Metastasis occurred in heart, lungs, spleen, kidneys and gonads. It can be concluded that liver is the target organ for tumourogenesis following RSV infection and can therefore be effectively used as a marker for genetic studies.


Key words

Chorioallantoic membrane, histopathology, liver tumour, Rous sarcoma virus.


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