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International Journal of Technology
Year : 2019, Volume : 9, Issue : 2
First page : ( 45) Last page : ( 53)
Print ISSN : 2231-3907. Online ISSN : 2231-3915.
Article DOI : 10.5958/2231-3915.2019.00011.7

Analytical Method for Determination of Thiocolchicoside in marketed Pharmaceutical Preparation: A Review

Ankush P. Jadhav, Datar P.A., Shete R.V.

Department of Pharmaceutical Quality Assurance, Rajgad Dnyanpeeth's College of Pharmacy, Bhor-Pune, Maharashtra, Pin-412206

Abstract

Thiocolchicoside a natural anti-inflammatory glycoside. It is the semi-synthetic derivative of the colchicine. It is a muscle relaxant with anti-inflammatory and analgesic effects. It works through selective binding to the GABA-A receptor. It prevents muscle contractions by activating the GABA inhibitory motor pathway. The article summarizes analytical method including the chromatographic method, LC-MS (Liquid Chromatography-mass spectroscopy), HPLC, GC-MS (Gas chromatography-mass spectroscopy), HPTLC and UV-Visible spectrophotometry techniques for estimation of Thiocolchicoside in biological samples, bulk and pharmaceutical formulation.

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Keywords

Thiocolchicoside (THC), UV-Spectrophotometry, HPLC, HPTLC, LC-MS, GC-MS.

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