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International Journal of Technology
Year : 2017, Volume : 7, Issue : 2
First page : ( 90) Last page : ( 95)
Print ISSN : 2231-3907. Online ISSN : 2231-3915.
Article DOI : 10.5958/2231-3915.2017.00015.3

Synthesis, Characterization and Evaluation of substituted Benzimidazole hydrazine Carboxamide derivatives for Antiinflammatory activity

Gupta Vishal1,*, Kumar Gautam Girendra2, Yadav S.K.3

1Research Scholar, Institute of Pharmaceutical Science and Research Center, Bhagwant University, Ajmer, Rajasthan, India

2Supervisor, Institute of Pharmaceutical science and research center, Bhagwant University, Ajmer, Rajasthan, India

3Supervisor, Technocrat Institute of Technology-Pharmacy, Anand Nagar, Bhopal, India

*Corresponding Author E-mail: vishalpharmacy@rediffmail.com

Online published on 5 April, 2018.

Abstract

A series of Benzimidazole derivatives were synthesized by condensation of N-(1H-benzimidazol-5-yl)hydrazine carboxamide with various isatin derivatives and evaluated for their anti-inflammatory activity using carrageenan induced rat paw edema model. The synthesized compounds 7a-7h were characterized by spectral data (IR, 1H-NMR and mass) and elemental analysis. All the novel benzimidazole derivatives exhibited mild to moderate activity. Compound 7b, 5-methyl isatin derivative exhibited better anti-inflammatory activity compared with control and other test compounds with percentage inhibition of 71.75.

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Keywords

Benzimidazole, anti-inflammatory agents, carrageenan induced rat paw edema.

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