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International Journal of Research in Social Sciences
Year : 2012, Volume : 2, Issue : 4
First page : ( 705) Last page : ( 718)
Online ISSN : 2249-2496.

A1, A2 beta casein variants in cows – Its impact on modern human health

Sharma Narotam*, Sharma Veena**, Nautiyal Satish Chandra, Singh Prem Raj, Kushwaha R.S., Sailwal Shivani, Ghosh Shayan, Naushad Ahmer, Singh R.K.

*Molecular Research Laboratory, Department of Biochemistry, Shri Guru Ram Rai Institute of Medical & Health Sciences, Patel Nagar, Dehradun-248001. (U.K.) India

**Department of Bioscience and Biotechnology, Banasthali University, Banasthali-304022, Rajasthan

Online published on 8 October, 2013.

Abstract

Milk from a variety of animal species has been included in the diet not only for infants, but also for human adults. Indian breeds of cows are called Bos Indicus. Common forms of beta-casein in are A1 and A2, while B is less common, and A3 and C are rare. At position 67th of the beta-casein chain, proline in variant A2 is substituted by histidine in variant A1. Milk of ancient breeds of cows is called A2 milk. During digestion, proteins in milk are broken down in to peptides. Most of these peptides get converted into amino acids to be absorbed by the blood stream few got excreted in stools and a quantity of manage to get through the leaks in gut wall in to the blood stream while still in peptide form. A1 milk releases Betacasomorphine 7(BCM7), an opium family substance, associated with number of diseases. In Infants Blood Brain Barrier is formed in human body after 3 to 4 years age associated with Autism, Diabetes type 1 and Sudden Death Syndrome in infants. In Adults BCM7 has been implicated in very high incidence of Ulcerative colitis, CAD, (Heart related diseases) Diabetes, Multiple sclerosis, Mental disorders Parkinson & Schizophrenia.

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Keywords

Beta casomorphin7, autism, bos Taurus, atherosclerosis.

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