Comparison of Fibroblast amount on the Gingival Healing Process in the Wound Applied by Platelet-rich Plasma (PRP) and chlorhexidine (CHX)
This study was aimed to compare the amount of the fibroblast on the gingival healing process using platelet-rich plasma (PRP) and chlorhexidine (CHX).
Materials and Method
Fifteen homogen mice were included in this study. Five mice in PRP group, five in CHX group and four in control group. One mice was sacrificed for PRP preparation. 10 mm incision was made in mandibular gingiva and applied with PRP and CHX according to their group. The fibroblast of the healing process were analyzed with electron microscopic at the 1st, 3rd, and 5th day.
In histopathologicanalysis, the healing process was greater in the experimental group than in control group on 1st and 3rd day, with the increasing amount of the fibroblast. The fibroblast enhanced significantly with P>0.009, but on the 5th day the healing process was average at the experimental and control group.
The addition of PRP significantly increased gingiva healing process. PRP were important because of the growth factor and may be useful in the future to increase the healing process.
The goal of the periodontal treatment are enhance periodontal health and obtain gingival aesthetic. All these goals are depend on the success of the healing process which can be obtained from the periodontal surgery. Nowadays, clinician use Platelet-Rich Plasma (PRP) to enhance the healing process.
Periodontal healing, PRP, Wound Healing.