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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 5
First page : ( 604) Last page : ( 609)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.01073.8

Comparison of Fibroblast amount on the Gingival Healing Process in the Wound Applied by Platelet-rich Plasma (PRP) and chlorhexidine (CHX)

Rieuwpassa Irene E.1, Tanca Misnova2, Sri Oktawati2, Djais Arni Irawaty2, Cangara Muhammad Husni3, Achmad Harun4

1Department of Oral Biology, Hasanuddin University, Makassar, Indonesia

2Department of Periodontology, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

3Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

4Department of Pedodontic, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

Online published on 4 June, 2019.



This study was aimed to compare the amount of the fibroblast on the gingival healing process using platelet-rich plasma (PRP) and chlorhexidine (CHX).

Materials and Method

Fifteen homogen mice were included in this study. Five mice in PRP group, five in CHX group and four in control group. One mice was sacrificed for PRP preparation. 10 mm incision was made in mandibular gingiva and applied with PRP and CHX according to their group. The fibroblast of the healing process were analyzed with electron microscopic at the 1st, 3rd, and 5th day.


In histopathologicanalysis, the healing process was greater in the experimental group than in control group on 1st and 3rd day, with the increasing amount of the fibroblast. The fibroblast enhanced significantly with P>0.009, but on the 5th day the healing process was average at the experimental and control group.


The addition of PRP significantly increased gingiva healing process. PRP were important because of the growth factor and may be useful in the future to increase the healing process.

Clinical Significance

The goal of the periodontal treatment are enhance periodontal health and obtain gingival aesthetic. All these goals are depend on the success of the healing process which can be obtained from the periodontal surgery. Nowadays, clinician use Platelet-Rich Plasma (PRP) to enhance the healing process.



Periodontal healing, PRP, Wound Healing.


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