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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 2
First page : ( 473) Last page : ( 478)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.00336.X

Correlation Tuberculosis Drugs Treatment Phase with SGPT/Bilirubin Total Level and Correlation both of the Enzymes from TB Patients

Thuraidah Anny1, Naily Jihan Rahmah1, Hasanah Nadiya Uswatun1, Lutpiatina Leka1

1Medical Laboratory Technology, Poltekkes Kemenkes Banjarmasin, Mistar Cokrokusumo Street 4a, Banjarbaru, Indonesia

Online published on 8 March, 2019.

Abstract

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis that can infect some organs of the body such as lungs, kidneys, and bones. Multidrug therapy method using Isoniazid, Rifampicin, Ethambutol, Pyrazinamide, and Streptomycin. Anti Tuberculosis Drugs (ATD) have side effects on the liver, skin, and nerves. Unwanted one is hepatotoxic. This research aims to determine correlation long of ATD administration with total Bilirubin and SGPT level from pulmonary TB patients at Sungai Tabuk 1, and Martapura Barat PHC also determines a correlation between the Total Bilirubin with the SGPT. 25 people as the sample with accidental sampling technique. This research is the analytic survey with cross-sectional study design. The results is 1.36 mg/dL for 0–2 months, 3–4 months were 1.19 mg/dL, and 5–6 months1.13 mg/dL for mean of Total Bilirubin and 30, 58 u/l, 19, 83 u/l dan 15, 16 u/l for mean SGPT level. Spearman test is p 0, 001 for Bilirubin; 0, 002 for SGPT with duration ATD administration and 0, 000 between those enzymes. A conclusion is there is the significant correlation between duration of administration ATD with total Bilirubin (−0, 632) and SGPT (−0, 597) While the decrease of level value from both enzymes had the strong correlation (0, 972). Recommended for further research to the same respondents with another ATD.

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Keywords

ATD, Treatment Phase, SGPT, Total Bilirubin.

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