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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
First page : ( 1476) Last page : ( 1481)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.03045.6

Analysis of VDR Gene Expression and its Relationship with Bacterial Load in Typhoid Fever Patients

Efendi Suradi1,2,*, Budu3, Hatta Mochammad4, Natsir Rosd iana5, Sriyanah Nour6, Maryunis7, Dwiyanti Ressy4

1Nursing Study Program, Sekolah Tinggi Ilmu Kesehatan, Makassar, Indonesia

2Doctoral Students, Post Graduate School, Universitas Hasanuddin, Makassar, Indonesia

3Ophthalmology Department Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

4Molecular Biology and Immunology Department Faculty of Medicine, Universitas Hasanuddin, Makassar

5Biochemistry Department Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

6Nursing Study Program, Sekolah Tinggi Ilmu Kesehatan, Makassar, Indonesia

7Public Hospital of Dr. Wahidin Sudirohusodo, Makassar, Indonesia

*Corresponding author: Suradi Efendi1, E-mail: atolnurse@gmail.com, 08114111075

Online published on 23 December, 2019.

Abstract

In Indonesia, Typhoid must be taken seriously from various parties, because this disease is endemic and threatening public health. The vitamin D receptor gene (VDR) has been involved in modulation of susceptibility on inflammatory conditions including typhoid fever.

This study aimed at investigating VDR genes expression and its relationship with bacterial load in typhoid fever patients

This study used analytical survey design with cross-sectional approach, which focuses on Vitamin D Receptor (VDR) genes expression and its relationship with bacterial load in typhoid fever patients. The total sample was 55 sufferers. The statistical test used was Mann U Whitney with the confidence degree of 95% and value of α <0.05. All data were analyzed using the SPSS Version 21.0 program.

The results showed the weak VDR gene expression (47.3%) and the strong one (52.75%), bacterial load was in the average at 43, 583, 636.36 ± 75, 649, 400.29, and there was relationship between VDR gene expression with bacterial load (p <0.001), which is the bacterial load tendency is higher in patients with weak VDR gene expression than the strong one.

Strong VDR gene expression decreases bacterial load in cases of typhoid fever.

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Keywords

VDR, bacterial load, typhoid fever.

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