Synthesis and Antibacterial Activity of Some New Derivatives Containing Thiazole moiety and Study of Their Effects on MAO Enzyme Activity (In vitro)
*Corresponding author: Amjad G. Eliwi., Department of Chemistry, College of Science, University of Mustansiriyah, Baghdad, Iraq; E-mail: a_amJadd@uomustansiriyah.edu.iq
The study includes synthesis and characterization of several heterocyclic systems such as 1, 2, 3 triazoles(5), some pyrazole derivatives(8a-c)and(12a, b), thaizolo(10) and chalcone derivatives(11a, b) by reaction of 4-nitro aniline with appropriate reagents. All synthesized derivatives containing thaizole moiety. These derivatives were characterized by IR, 1HNMR and mass spectroscopy. Newly synthesized compounds were in vitro screened against several bacterial species as well as S.aureus E.coli. effect of the prepared compounds were studied on monoaminooxidase (MAO) in healthy human serum. The results showed that all compounds cause competitive inhibition with enzyme except (2, 7b, 10, 11a, 12b) cause uncompetitive inhibition and (6, 8a, 8c) caused mixed inhibition.
Antibacterial activity, MAO activity, thiazol, pyrazol, 1, 2, 3triazol.