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International Journal of Medical Research & Health Sciences
Year : 2016, Volume : 5, Issue : 8
First page : ( 257) Last page : ( 263)
Online ISSN : 2319-5886.

The effect of salvia officinalis tablet on hot flashes, night sweating, and estradiol hormone in postmenopausal women

Rad Sima Kiani1, Forouhari Sedighe2,*, Dehaghani Alamtaj Samsami3, Vafaei Homeira4, Sayadi Mehrab5, Asadi Maryam1

1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

2Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3Infertility Research Center, Reproductive Endocrinology and Infertility Division, Department of OB-GYN, School of Medicine Shiraz University of Medical Sciences, Shiraz, Iran

4Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

5Student of biostatistics, Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

*Corresponding E-mail: forouharism@yahoo.com

Online published on 29 September, 2018.


Hot flashes and night sweats associated with menopause are the most annoying symptoms among premenopausal women and have been ranked as the first reason for referral to medical centers. The common treatment for this symptom is administration of Hormone Replacement Therapy (HRT) that has some adverse effects and is sometimes contraindicated. Therefore, use of herbal drugs that have fewer side effects needs to be investigated. This study aimed to investigate the influence of salvia tablets on hot flashes, night sweats, and estradiol hormone in postmenopausal women referring to healthcare centers in Shiraz. This double-blind randomized clinical trial was performed on 100 qualified postmenopausal women with hot flashes. The study women were divided into two groups daily treated with 3 salvia or placebo tablets (100 mg) for 8 weeks. Estradiol hormone and menopause symptoms were evaluated using Menopause Rating Scale(MRS)1 week before and 8 weeks after the beginning the intervention. Besides, duration, intensity, and frequency of hot flashes and night sweats were evaluated every week, and the two groups were compared in terms of these variables. The results showed no significant difference between the two groups regarding demographic information, hot flashes, night sweats, and other menopause symptoms in MRS scale before the intervention. After 8 weeks, however, hot flashes, night sweats, and MRS scores significantly decreased in the saliva group compared to the control group. However, no significant difference was observed between the two groups concerning the estradiol levels. Yet, the results of intra-group analysis showed that the level of this hormone increased in the sage group. Sage tablets were effective in treatment of hot flashes, night sweats, and other menopausal symptoms in postmenopausal women. Thus, they can be considered as an alternative therapy for the individuals who are not able to use HRT.



Saliva, Hot flashes, Night sweating, Estradiol.


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