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International Journal of Medical Research & Health Sciences
Year : 2013, Volume : 1, Issue : 2
First page : ( 70) Last page : ( 77)
Online ISSN : 2319-5886.

A study of anti-hyperlipidemia, hypolipedimic and anti-atherogenic activity of fruit of emblica officinalis (AMLA) in high fat fed albino rats

Jeevangi Santoshkumar1,*, Manjunath S2, Sakhare Pranavkumar M3

1Associate Professor, Department of Pharmacology, M.R Medical College, Gulbarga, Karnataka, India

2Professor, Department of Pharmacology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India

3Post Graduate Student, Department of Pharmacology, M.R Medical College, Gulbarga, Karnataka, India

*Corresponding author email: drsantoshkumar.2007@rediffmail.com

Online published on 6 April, 2013.

Abstract

Background

Emblica Officinalis (Amla), belonging to the genus, Phyllanthus emblica is widely used for medicinal purpose. Its fruits have been used traditionally as a hypolipidemic.

Objectives

The present study was aimed to evaluate hypolipedimic and anti-atherogenic activity of fruit of Emblica officinalis in high fat fed albino rats.

Materials and Methods

For study of anti-hyperlipidemic, hypolipidemic, and anti-atherogenic activity. 5 groups of 6 animals in each received normal saline, E. Officinalis powder, high fat diet, High fat diet plus E. Officinalis powder both and Atorvastatin respectively for 8 weeks. Hyperlipidemia was induced by feeding animals with high fat diet per orally, consisting of coconut oil and vanaspati ghee, daily ad libitum. At the end of the study, blood samples of the animals were sent for the estimation of the lipid profile and effects of test drug studied by comparing levels of Total Cholesterol, Triglycerides, HDL, LDL, and Atherogenic index. The statistical significance between groups was analysed by using one way ANOVA, followed by Dunnet's multiple comparison test.

Results

Fruit of Amla showed significant anti-hyperlipidemic, hypolipidemic, and anti-atherogenic effect. All these effects may contribute to its anti-atherogenic activity.

Conclusion

Present study revealed the antihyperlipidemic, hypolipidemic, and anti-atherogenic effect of Amla fruit powder and can be safely used in the treatment of mild to moderate cases of hyperlipidemia considering its easy availability, cost effectiveness, and other beneficial effects.

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Keywords

Emblica Officinalis, Hypolipidemic, Anti-Atherogenic, Atorvastatin, Atherogenic Index.

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