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Indian Journal of Mednodent and Allied Sciences
Year : 2017, Volume : 5, Issue : 3
First page : ( 219) Last page : ( 223)
Print ISSN : 2347-6192. Online ISSN : 2347-6206.
Article DOI : 10.5958/2347-6206.2017.00036.X

Revisiting the Efficacy of Immunomodulatory Effect of Hydroxychloroquine in Oral Lichen Planus: A Case Series

Dayanandam Mala1,*,  Pushpanjali2, Pasupuleti Pravallika3, Satya Neeharika4, Jyothi Seelam Divya5, Sree M. Satya5

1Assistant Professor, Department of Oral Medicine and Radiology, Government Dental College and Hospital, RIMS, Kadapa, Andhra Pradesh, India

2Assistant Professor, Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, RIMS, Kadapa, Andhra Pradesh, India

3Post Graduate Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, India

4Senior Resident; Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, India

5Post Graduate Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, India

*Corresponding author mail id: sindhudentalsdnr@gmail.com

Online published on 14 March, 2018.

Abstract

Oral lichen planus (OLP) is a common inflammatory, autoimmune disorder that affects stratified squamous epithelium. The exact etiopathogenesis of this mucocutaneous disease is still uncertain. Although OLP has been associated with altered Quality of Life and considerable morbidity, with important note for erosive type of OLP, its treatment is often disappointing and controversial. Though corticosteroids remained the first line of treatment for OLP, the associated adverse effects of corticosteroids are not acceptable. Hence, there is a need of drugs with steroid sparing effect. Use of immunomodulators is systemic pathologies is widely encountered. However, their use in oral lesions is not frequently seen. Use of hydroxychloroquine (HCQ), an age-old disease-modifyinganti-rheumatic-drug, has been widely used in various autoimmune diseases; however, it received little attention in treatment of OLP. This article presents a case series of three patients with erosive OLP which were managed with HCQ. The results presented allow the authors to consider systemic HCQ as a newer therapy for atrophicerosive lichen planus.

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Keywords

Cell-mediated immunity, Hydroxychloroquine, Immunomodulators, Mucocutaneous disorders, Potentially malignant disorders, T lymphocytes.

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