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Indian Journal of Mednodent and Allied Sciences
Year : 2017, Volume : 5, Issue : 2
First page : ( 110) Last page : ( 114)
Print ISSN : 2347-6192. Online ISSN : 2347-6206.
Article DOI : 10.5958/2347-6206.2017.00018.8

Estimation of Serum Folate and Homocysteine Levels in Oral Submucous Fibrosis-A Prospective Study

 Pushpanjali1,  Dayanandam2,*, Satyasree M.3, Divya Seelam3, Pasupulati Pravallika3,  Vasundhara3

1Associate Professor, Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, RIMS, Kadapa, Andhra Pradesh, India

2Assistant Professor, Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, India

3Post Graduate, Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, India

*Corresponding author email id: sindhudentalsdnr@gmail.com

Online published on 25 September, 2017.

Abstract

Aim & Objective

The aim of the study was to evaluate the levels of serum folate and homocysteine in clinical stages of Oral submucous fibrosis (OSF) patients.

Methodology

The study sample comprised of 40 clinically and histopathologically diagnosed OSF patients those who are not undergoing treatment and 10 healthy controls. OSF was categorised by clinical staging. Serum foliate and homocysteine levels estimation was done by reverse phase high performance liquid chromatography analysis unit and chemiluminescence immuno assay, respectively. Results were statistically analysed using one-way ANOVA [Analysis of variance].

Results

Irrespective of age and gender, serum folate deficiency and high levels of homocysteine were noted in OSF patients when compared with healthy controls.

Conclusion

Serum hyper homocysteinemia and folate deficiency were noted with the progression of the disease. Folate supplements can be given to decrease the levels of homocysteine, to arrest the progression of the disease. However, further longitudinal studies are needed to establish an association between serum homocysteine and serum folate.

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Keywords

Oral submucous fibrosis, Serum folate, Serum homocysteine Histo pathology, Anova, HPLC, Oxidative DNA, Carcinogenesis.

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