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Indian Journal of Forensic Medicine & Toxicology
Year : 2019, Volume : 13, Issue : 1
First page : ( 372) Last page : ( 377)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2019.00072.0

Evaluation and Study of Recrystellization on Polymorph of Dexamethasone by Using GC-MS and FT-IR Spectroscopy

Aljarah Ali Kadhim1, Hameed Imad Hadi2,*, Hadi Mohammed Yahya3

1Department of Biology, College of Science for Women, University of Babylon, Hillah city, Iraq

2Biomedical Science Department University of Babylon, College of Nursing, Hillah City, Iraq

3Department of Biotechnology, College of Biotechnology, Al-Qasim Green University, Iraq

*Corresponding author: Imad Hadi Hameed, Biomedical Science Department, University of Babylon, College of Nursing, Hillah city, Iraq; Phone number: 009647716150716; E-mail: imad_dna@yahoo.com

Online published on 8 February, 2019.

Abstract

Polymorphism is the phenomena where drug exists in more than one crystalline form. Though polymorphs are chemically identical, they exhibit different physicochemical properties like solubility which further affect the biological properties of drugs. The purpose of this work was to study the effect of solvents of different polarity and processing conditions on crystallization and physicochemical properties of Dexamethasone. The crystals were prepared from different polarity of solvents and processing conditions like deep freezing, law temperature cooling (4C°) and room temperature. The Fourier Transform Infra-Red and Microscopy studies were carried out to check for polymorphism in drug. The result indicate that crystal obtained from different solvents and processing conditions exhibited different physicochemical properties. FT-IR gave an indication of difference in the spectra. The crystals with different properties can be obtained by changing solvent polarity and processing conditions.

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Keywords

Polymorphism, crystallization, Dexamethasone, FT-IR, GC-MS.

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