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Indian Journal of Forensic Medicine & Toxicology
Year : 2018, Volume : 12, Issue : 1
First page : ( 253) Last page : ( 258)
Print ISSN : 0973-9122. Online ISSN : 0973-9130.
Article DOI : 10.5958/0973-9130.2018.00050.6

S100b Level of Post Mortem Cerebrospinal Fluid and Serum in Blunt Head Trauma Cases

Susanti Rika1,*, Darwin Eryati2, Afandi Dedi3,  Yanwirasti4, Said Syahruddin5, Hidayat Taufik1, Rofinda Zelly Dia6

1Forensic and Legal Medicine Department Faculty of Medicine, Andalas University, Padang

2Histology Department Faculty of Medicine, Andalas University, Padang

3Forensic and Legal Medicine Department Faculty of Medicine, Riau University, Pekanbaru

4Anatomy Department Faculty of Medicine, University of Andalas, Padang

5Biotechnology Laboratory of LIPI Cibinong, West Java

6Clinical Pathology Department Faculty of Medicine, Andalas University, Padang

*Corresponding Author: Rika Susanti Forensic and Legal Medicine Department, Faculty of Medicine, Andalas University, Jl. Perintis Kemerdekaan No.94 PO. Box 49, Padang 25127, Mobile: +62 81372593763, E-mail: rikasusanti1976@yahoo.com

Online published on 19 January, 2018.

Abstract

Blunt head trauma is the leading cause of death in criminal cases. Various efforts have been made to find an alternative autopsy method to determine the cause of death. S100B level has been used as a biomarker in blunt head trauma for the living victims. The purpose of this study was to analyze the postmortem level of S100B in cerebrospinal fluid and serum particularly in determining the cause and the time of death. This experimental study used post test only group design. The treatment groups were divided into 8 groups. The samples of each group were 6 adults of Rattus novergicus variant sprague dawley. The S100B level was checked at 0 hour, 1 hour, 2 hours and 3 hours post mortem. Analysis of postmortem level of S100B in cerebrospinal fluid and serum used the general linear model repeated measure test. There is an elevation level of postmortem S100B in cerebrospinal and serum on the death due to blunt head trauma and acute ketamine poisoning. There is no significant difference of postmortem S100B level in cerebrospinal fluid and serum in the case of death due to blunt head trauma and acute ketamine poisoning.

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Keywords

blunt head trauma, S100B, cause of death, time of death.

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