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International Journal of Clinical Biochemistry and Research
Year : 2015, Volume : 2, Issue : 3
First page : ( 162) Last page : ( 165)
Print ISSN : 2394-6369. Online ISSN : 2394-6377.

A Comparative Study on Plasma Fibrinogen and hs-CRP in Metabolic Syndrome

Shifa K1,,*, Jithesh T.K.2, Warrior Parwathi K3, Liji K2

1Associate Professor, Dept. of Biochemistry, MES Medical College, Perintalmanna

2Assistant Professor, Dept. of Biochemistry, MES Medical College, Perintalmanna

3Professor, Dept. of Biochemistry, MES Medical College, Perintalmanna

*Corresponding Author: Email: kshifak@gmail.com

Online published on 5 January, 2016.

Abstract

Background &Objective

Metabolic syndrome (MS) comprises a group of various metabolic abnormalities related with high risk of cardiovascular disease. The relationship of plasma fibrinogen and hs-CRP levels with MS remains inconclusive. The aim of this study was to assess the correlation of fibrinogen and hs-CRP levels in metabolic syndrome.

Methods

It is a case control study. Detailed clinical, epidemiological and anthropometric characteristics were recorded using pro-forma. 5ml fasting venous blood collected from all the subjects after getting the informed consent. The blood samples thus obtained was used for studies including Lipid profile, hs-CRP, blood sugar and plasma fibrinogen.

Results

Fibrinogen and hs-CRP levels show significant increase in MS group. But there is no significant correlation between fibrinogen and hs-CRP levels.

Interpretation & Conclusion

Hyper fibrinogenemia and an increase in hs-CRP level in the test population explain the increased cardiovascular risk. Plasma determination of these inflammatory biomarkers might have a role in predicting the severity of metabolic syndrome.

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Keywords

Metabolic syndrome, Fibrinogen, hs-CRP.

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