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Indian Journal of Animal Research
Year : 2020, Volume : 54, Issue : 3
First page : ( 335) Last page : ( 341)
Print ISSN : 0367-6722. Online ISSN : 0976-0555.
Article DOI : 10.18805/ijar.B-1083

Protective effects of selenium on malathion-induced testicular toxicity in mice

Ibrahim Mahrous A.1,2, Wani Farooq A.3,*, Khalifa Athar M.3, Kelleni Mina T.4,5, Anwar Marwa M.2, Thirunavukkarasu Ashokkumar6, Sayeed Mohammed U.3

1Forensic Medicine and Clinical Toxicology, College of Medicine, Jouf University, Sakaka, Saudi Arabia

2Forensic Medicine and Clinical Toxicology Department Faculty of Medicine, Suez Canal University (SCU), Ismailia, Egypt

3Pathology Department, College of Medicine, Jouf University, Sakaka, Saudi Arabia

4Pharmacology department, Faculty of Medicine, Minia University, Egypt

5Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia

6Community Medicine Department, College of Medicine, Jouf University, Sakaka, Saudi Arabia

*Corresponding Author: Farooq A. Wani, Pathology Department, College of Medicine, Jouf University, Sakaka, Saudi Arabia. Email: farooqafroza@gmail.com

Online published on 8 April, 2020.

Abstract

The aim of this study was to investigate the possible protective effect of the antioxidant sodium selenite (0.1 mg/kg/day) via gavage once a day for 30 days for the first time in a model of malathion (27 mg/kg/day) via gavage once a day for 30 days induced testicular toxicity in mice. Results of this study revealed that concomitant administration of selenium has prevented the decrease in mean final and relative body weight as well as testicular and relative testicular weight as compared to malathion group. Concomitant selenium administration has also decreased malondialdehyde contents and increased serum levels of follicle stimulating hormone, luteinizing hormone, testosterone, acetylcholinesterase and testicular levels and activities of glutathione, glutathione peroxidase, catalase, superoxide dismutase and improved the testicular histopathological features as compared to malathion group.

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Keywords

Organophosphate pesticides, Oxidative stress, Selenium, Testicular toxicity.

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