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Indian Journal of Animal Research
Year : 2019, Volume : 53, Issue : 4
First page : ( 523) Last page : ( 527)
Print ISSN : 0367-6722. Online ISSN : 0976-0555.
Article DOI : 10.18805/ijar.B-853

Baicalein ameliorates cadmium-induced hepatic and renal oxidative damage in rats

Wang Jicang1,*, Zhu Huali2, Zhang Cai1, Wang Hongwei1, Yang Zijun1

College of Animal Science and Technology, Henan University of Science and Technology, No. 263, Kaiyuan Avenue, 471023, Luoyang, PR China

1College of Animal Science and Technology, Henan University of Science and Technology, No. 263, Kaiyuan Avenue, 471023, Luoyang, PR China

2Law Hospital, Henan University of Science and Technology, No.263, Kaiyuan Avenue, 471023, Luoyang, PR China

*Corresponding author's e-mail: wangjicang@126.com

Abstract

Cadmium (Cd)-induced oxidative damage of liver and kidney and the ameliorative impact of baicalein against hepatotoxicity and nephrotoxicity of rats was studied. Male SD rats were handled with either intraperitoneal cadmium (CdCl2, 2mg/kg) and/or oral baicalein (100 mg/kg) for 4 weeks. The results demonstrated that Cd increased the level of GPT, GOT, BUN in serum and the contents of MDA, GSH, decreased the activities of SOD, CAT, GSH-Px in tissues versus control. Conversely, administration of baicalein restored the changes in these parameters to nearly normal levels. The results suggested that the ameliorative impact of baicalein might be because of its antioxidant properties in combating free radical-induced oxidative stress resulting from cadmium chloride.

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Keywords

Baicalein, Cadmium, kidney, Liver, Oxidative stress.

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