Trimethylaminuria (Fish odor syndrome): Etiopathophysiological bases of clinical manifestations and treatment and nursing modalities.
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Have you seen someone is emitting fishy odor or smell through his/her mouth or body secretions? Yes, it is possible in condition called as fish odor syndrome or trimethylamnuria. It is one of the metabolic, genetic disorder in which the body is unable to breakdown trimethyalmine (strong smelling chemical) which is produced by micro enterobacteria in an intestine during digestion of protein in to trimethylamine oxide (odor less chemical) which results in accumulation of trimethylamine in all body secretions and results in fishy odor in mouth, sweat, vagina and in urine. This type of disease mainly caused by mutation of gene called as Flavincontaining monooxygenase 3 (FMO3) and also resulted by eating choline or nitrogen containing foods such as eggs, liver, legumes, soybeans, peas, pea nuts, certain kind of fish, broccoli, cabbage, tomato, potato and other foods. Finally accumulation of trimethylamine in body secretions which results in giving off fishy odor. This condition is diagnosed by urine test, trimethylamine load test and gene testing. We can treat this disease by medical and nursing modalities such as use of antibiotics, diet control, nursing counseling, maintaining personal hygiene, use of active charcoal, taking laxatives, music therapy psychotherapy, use of copper and riboflavin supplements.
Trimethylaminuria, choline, fishy odor, nursing, counseling, music, riboflavin, gene testing.