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Current Trends in Biotechnology and Pharmacy
Year : 2009, Volume : 3, Issue : 1
First page : ( 97) Last page : ( 104)
Print ISSN : 0973-8916. Online ISSN : 2230-7303.

Development of a Novel Transdermal Ibuprofen Ointment

Aukunuru Jithan*, Chinnala Krishna Mohan, Guduri Viswanath

Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal-506001(Andhra Pradesh)India.

* For Correspondence: aukunurujithan@hotmail.com

Abstract

The present work was undertaken to develop and evaluate transdermal ointments of ibuprofen containing supersaturated drug and menthol as a penetration enhancer. Trandermal ointments were prepared using white petrolatum, bees wax, propylene glycol, PEG 400 and menthol using a fusion technique. Microscopy was used to determine the supersaturation of the drug in the vehicle. The formulated ointments were subjected to in vitro release studies and skin permeation studies. These studies were conducted in the diffusion cells developed in our laboratory, specifically for this purpose. Selected formulations were evaluated for their anti-inflammatory activity using the carrageenan-induced paw edema in rats. The formulation containing menthol demonstrated more transport across the skin. The final formulations selected for topical and systemic investigation had menthol in both the formulations. The results corroborated the fact that the drug was released into the systemic circulation from ibuprofen ointments after topical application with one containing penetration enhancer releasing more. The study clearly indicates that trans-dermal delivery of ibuprofen using a topical petrolatum base ointment is a viable option.

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Keywords

transdermal, ointment, ibuprofen, co-solvency, solubility, carrageenan.

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