Role of Professionally Applied 0.8% Hyaluronic Acid Gel in Managing Inflammation in Periodontal Disease
Address for Correspondence: Dr. Rajan Gupta, Department of Periodontology and Oral Implantology, H.I.D.S. Paonta Sahib Himachal Pradesh India
Hyaluronic acid (HA) is crucial for the control of inflammation and promotion of subsequent wound healing. Anti-inflammatory effects of single subgingival application of HA gel alone and immediately after scaling and root planing were evaluated in this study.
Twenty five patients with chronic periodontitis were enrolled in this split mouth study. Plaque Index (PI), Eastman Interdental Bleeding Index (EIBI), Gingival Colour Change Index (GCCI) were evaluated at baseline 3, 7 & 21 days; probing depth (PD), clinical attachment level (CAL) were monitored at baseline and 21 days. Patient's mouth was randomly divided into four quadrants based on scaling and root planing + immediate insertion of HA gel (GpA), scaling and root planing alone (GpB), insertion of HA gel alone (GpC) and no treatment (GpD).
Significant improvement of PI and EIBI was observed in all the four groups. Significant improvement of all the clinical variables was observed in Group A and Group B (P<0.05). Statistically significant difference in mean score of EIBI was found between Group A and Group Bat 3, 7 days only. No long term effect of HA gel was observed.
Short term clinical improvement was achieved by adjunctive use of HA gel as compared to SRP alone. No additional clinical improvement was observed by use of HA gel over the sites where no treatment was done.
Hyaluronic acid, periodontitis, scaling, root planing, subgingival application.