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Asian Journal of Research in Pharmaceutical Science
Year : 2019, Volume : 9, Issue : 3
First page : ( 186) Last page : ( 192)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2019.00029.8

Protective Potential effect of Gloriosa superba Linn. against lead Nitrate Induced Oxidative stress in Rats.

Umarani Vadapalli1,*, Sudhakar Muvvala1, Ramesh Alluri2

1Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally (Via Hakimpet), Maisammaguda, Secunderabad, 500014, Andhra Pradesh, India

2Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Telangana, India

*Corresponding Author E-mail: ranileo.rani@rediffmail.com

Online published on 3 January, 2020.

Abstract

Gloriosa superba Linn. is an inexpensive and efficient source to provide all the required nutrients and medicinal benefits for a healthy and rejuvenating body. The present investigation has been undertaken to evaluate the role of Gloriosa superba Linn. in modifying the lead nitrate induced biochemical alterations in albino rats. Administration of lead nitrate in rats induces oxidative stress, which leads to the generation of free radicals in the body. These free radicals interact with tissue leading to liver and kidney damage. Exposure to lead significantly increased malondialdehyde levels with a significant decrease in superoxide dismutase and catalase activities, and the concentration of GSH in the liver and kidneys of rats. Significantly increased levels of AST, ALT, ALP, BUN and serum creatinine and decreased levels of total protein were observed. The administration of lead significantly decreased the body weight and organ weights at the end of the experimental period. Statistically significant decrease in hemoglobin, red blood cell and total leukocyte count was observed. Pretreatment of hydroalcoholic extract of Gloriosa superba Linn. to lead exposed rats significantly ameliorated lead-induced oxidative stress in tissues and produced improvement in hematological parameters over lead-exposed rats, indicating the beneficial role of Gloriosa superba Linn. to counteract the lead-induced oxidative stress.

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Keywords

Lead nitrate, Gloriosa superba Linn. oxidative stress, liver, kidney.

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