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Asian Journal of Research in Pharmaceutical Science
Year : 2019, Volume : 9, Issue : 3
First page : ( 163) Last page : ( 168)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2019.00025.0

Degradation Study of Furosemide by UV-Visible Spectrophotometry Method in bulk form

Chavan Rohankumar R.*, Bhinge Somnath D., Bhutkar Mangesh A., Randive Dheeraj S.

Dept of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-416404

*Corresponding Author E-mail: rohankumar3102@gmail.com

Online published on 3 January, 2020.

Abstract

Furosemide, a widely used “high-ceiling” loop diuretic drug, is indicated for congestive heart failure, chronic renal failure, and hepatic cirrhosis. Degradation is a main problem in numerous unstable products. As per the ICH guidelines factors which causes degradation of a drug product comprise of temperature, time, photo degradation, pH variation (high and low), acid/base stress testing and/or with humidity. In our research work UV-V spectroscopy method was designed to examine and calculate the quantity of drug in the presence of degradation products. WHO, the official assay limit of the content should not less than 98% and not more than 102% of labelled amount of the estimated potency. From the results of our study it can concluded that Furosemide degrades most when exposed to the acidic medium and heat, whereas slight degradation occurs in basic medium and UV light.

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Keywords

Furosemide, Degradation, UV-Spectrophotometry.

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