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Asian Journal of Research in Pharmaceutical Science
Year : 2019, Volume : 9, Issue : 2
First page : ( 85) Last page : ( 90)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2019.00013.4

A Review on effectiveness of different Antiepileptic Drugs in Pediatric Febrile Szeizures

Mendem Anusha*, Arma Mamatha, Mugada Vinodkumar, Kolakota Raj kiran

Department of Pharmacy Practice, Vignan Institute of Pharmaceutical Technology, Duvvada, Andhra Pradesh, India

*Corresponding Author E-mail: ponnyanushaa@gmail.com

Online published on 3 July, 2019.

Abstract

Febrile convulsions (FCs) are defined as seizures that occur in children between 6 months and 5 years of age, associated with fever but without intracranial infection or defined causes. The risk of developing epilepsy from a simple FC is 1.0–2.4%, and from a complex FC is 4.1–6.0%. The aim of the study was to assess the effectiveness of antiepileptic drugs in pediatric seizures. The data bases searched are pub med, trip database, science direct and Cochrane library The Type of study is observational studies and randomized control trails. In this study considerable Study population are Infant (1 month) to 6 yrs children. Intervention related to effective treatment of antiepileptic drugs in pediatrics. Patients with only febrile seizures and there treatment are included. Interventional studies are excluded. Children above 6 yrs age and adults are excluded. Patients other than febrile seizures are also excluded. In continuous anticonvulsant therapy, Phenobarbitone is most effective in prevalence of reoccurrence of febrile seizures, Valproic acid is least effective, Carbamazepine and phenytoin does not show any effective. In intermittent anticonvulsant therapy Diazepam is most effective. The effective dugs of antiepileptic drugs in pediatric seizures, Benzodiazepines given intravenously, liquid Diazepam is a safe, effective, and rational alternative. Phenobarbital is effective in recurrence of simple febrile seizures.

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Keywords

Pediatrics, febrile seizures, antiepileptic drugs.

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