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Asian Journal of Research in Pharmaceutical Science
Year : 2018, Volume : 8, Issue : 4
First page : ( 241) Last page : ( 246)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2018.00040.1

Development of Metoprolol Tartrate Sustained Release Formulations by using Modified Starches

Murthy T. E. Gopala Krishna, Akash V.*

Dept. of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India

*Corresponding Author E-mail: aakashvemuri999@gmail.com

Online published on 25 December, 2018.

Abstract

The present study was under taken to develop sustained release formulations for Metoprolol tartrate, a β-blocker for the treatment of Hypertension. The tablets were prepared by wet granulation technique by using modified starches as release retardant polymers. The evaluation involves 3 stages i.e. pre-compression, post compression parameters and in-vitro release kinetics assessment of tablets. The USP-II paddle method was selected to perform the dissolution test and 500ml of 6.8 pH phosphate buffer was used as dissolution medium at 50rpm at 37 C ± 0.5. The release kinetics was analyzed. All the formulations followed Peppa's release mechanism. When the release data was plotted into korsmeyer-Peppas equation (log cumulative % of drug release Vs log time), it was observed that all formulations (F2 to F11) (formulated with modified starches) followed Anamalous (non-Fickian) type of mechanism. The in-vitro release studies revealed that the formulation F5(formulated with Potato Starch containing 1: 4 drug: polymer ratio), F8(formulated with Corn Starch containing 1: 3 drug: polymer ratio) and F11 formulated with Rice Starch containing 1: 3 drug: polymer ratio) can be taken as ideal or optimized formulations for sustained release formulations as it fulfills all the requirements.

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Keywords

Sustained release formulations, Metoprolol tartrate, Potato starch, Corn starch, Rice starch, Calcium starch, In-vitro release kinetics.

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