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Asian Journal of Research in Pharmaceutical Science
Year : 2018, Volume : 8, Issue : 4
First page : ( 219) Last page : ( 222)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2018.00037.1

Effect of Antihypertensive Drugs on Homocysteine level among Hypertensive Patients

Rawat Rahul1, Joshi Yogesh2,*

1Pharm. D. (PB) Intern, Department of Pharmaceutical Science, Shri Guru Ram Rai Institute of Technology and Science, Dehradun-248001, Uttarakhand, India

2Assistant Professor, Department of Pharmaceutical Science, Shri Guru Ram Rai University, Dehradun-248001, Uttarakhand, India

*Corresponding Author E-mail: yogeshjoshi1583@rediffmail.com

Online published on 25 December, 2018.

Abstract

The present study was a prospective, cross-sectional, and observational study carried out for a period of six months to evaluate the effect of antihypertensive drugs on homocysteine level among hypertensive patients. A total of 70 patients were included in the study from inpatient department of medicine to assess the effect of antihypertensive drugs on their homocysteine level. Demographic Analysis revealed that out of 70 patients, 51% were males and 49% were females while maximum number of patients (28.57%) was found in age group of 5160 years. Patients taking telmisartan were categorized as group A containing 40 patients and patients taking amlodipine were categorized as group B containing 30 patients. Homocysteine level was initially taken before starting the antihypertensive drug treatment and finally taken after one or two weeks of follow-up visit. Result showed that homocysteine level decreases with telmisartan use and patients treated with amlodipine showed an increase in homocysteine level. The present study was concluded that homocysteine level decreases but not significantly after treatment with telmisartan whereas homocysteine level increases significantly after treatment with amlodipine.

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Keywords

Hypertension, homocysteine, antihypertensive drug, telmisartan, amlodipine.

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