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Asian Journal of Research in Pharmaceutical Science
Year : 2018, Volume : 8, Issue : 4
First page : ( 203) Last page : ( 209)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2018.00034.6

Process involves in the formation of tablet for novel drug delivery system

Sahdev Anil Kumar*, Purwar Somya

GNIT College of Pharmacy, Greater Noida, UP, India

*Corresponding Author E-mail: anilsahdev20@gmail.com

Online published on 25 December, 2018.

Abstract

Tablet is a unit solid dosage form, due to high precision dosing, manufacturing efficiency and patient compliance make tablet to most popular dosage forms. Compression (lessening in the bulk volume of material as a result of deracination of gaseous phase) and compaction (alteration of powder into coherent specimen) are the duet constitutive parts of tablet manufacturing. In this review discuss various types of excipients and their properties, including steps and mechanism of tablet compaction. Mechanistic aspects of tableting can be studied using several theories like mechanical theory, intermolecular theory, and liquid surface film theory. These all parameters have potential importance in various pharmaceutical research and development. Also, the mathematical equation used to characterize compaction and compression events. Compaction related physictechnical properties of commonly used tableting excipients have been reviewed with emphasis on selecting pleasantly combination to attenuate tableting problems. Specialized tools like co-processing of API and excipients properties like particle size and shape, surface area, density, strength and friability used to amend compression of tableting.

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Keywords

Tablet Excipients, Tablet Compaction, Compaction, Compression, Physics of Tablet compression, Equation of Compaction.

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