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Asian Journal of Research in Pharmaceutical Science
Year : 2018, Volume : 8, Issue : 1
First page : ( 21) Last page : ( 24)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2018.00005.X

Formulation and Evaluation of Rutin Loaded Nanosponges

Sri K. Vijaya*, Santhoshini Guda, Sankar D. Ravi, Niharika K.

Malla Reddy College of Pharmacy, (Affiliated to Osmania University), Secunderabad, Telangana

*Corresponding Author E-mail: vijayasree_2002@yahoo.co.in

Online published on 2 June, 2018.

Abstract

The main objective of this research was to develop rutin nanosponges and evaluate the potential of nanosponges for the delivery oral route. Rutin exhibited as antioxidant, anti-inflammatory, anti-allergic and antiviral activity. But its, poor absorption from the gastrointestinal tract is slow and irregular, probably due to their less solubility and slow dissolution rate. Rutin-loaded nanosponges were prepared by emulsion solvent diffusion method. Nanosponges were evaluated for various physicochemical parameters like FT-IR, DSC, entrapment efficiency, SEM, particle size, zeta potential and in vitro drug release. FT-IR study reveals the there was no physical and chemical interaction observed between the excipients and drug in combination. Rutinloaded nanosponges enhanced the drug release when compare to the pure rutin.

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Keywords

Rutin, Nanosponges.

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