(3.228.220.31)
Users online: 1757    [ij] [ij] [ij] 
Email id
 

Asian Journal of Research in Pharmaceutical Science
Year : 2017, Volume : 7, Issue : 4
First page : ( 189) Last page : ( 196)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2017.00029.7

Insulin Therapies: Current and Future Trends

Bhalerao Roshani*, Patil Akshay, Rishipathak Dinesh, Kshirsagar Sanjay

MET'S Institute of Pharmacy, Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik-422003, India

*Corresponding Author E-mail: roshanibhalerao55@gmail.com

Online published on 2 June, 2018.

Abstract

Many patients with advanced type 2 diabetes mellitus (T2DM) and all patients with T1DM require insulin to keep blood glucose levels in the target range. The most common route of insulin administration is subcutaneous insulin injections. There are many ways to deliver insulin subcutaneously such as vials and syringes, insulin pens, and insulin pumps. Though subcutaneous insulin delivery is the standard route of insulin administration, it is associated with injection pain, needle phobia, lipodystrophy, noncompliance and peripheral hyperinsulinemia. Therefore, the need exists for delivering insulin in a minimally invasive or noninvasive and in most physiological way. Inhaled insulin was the first approved noninvasive and alternative way to deliver insulin, but it has been withdrawn from the market. Technologies are being explored to make the noninvasive delivery of insulin possible. Some of the routes of insulin administration that are under investigation are oral, buccal, nasal, peritoneal and transdermal. This review article focuses on the various insulin delivery techniques. This article has focused on different possible routes of insulin administration with its advantages and limitation and possible scope for the new drug development.

Top

Keywords

Diabetes mellitus, inhaled insulin, insulin delivery, oral insulin, technology, closed-loop system, artificial pancreas.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
436,579,300 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.