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Asian Journal of Research in Pharmaceutical Science
Year : 2017, Volume : 7, Issue : 2
First page : ( 115) Last page : ( 119)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2017.00018.2

Synthesis, characterization and biological evaluation of benzothiazole derivatives as potential antimicrobial and analgesic agents

Kumar Konda Ravi1,*, Karthik K.N.S.1, Begum P. Reshma1, Rao Ch. M.M. Prasada2

1Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur

2Department of Pharm. Chemistry, QIS College of Pharmacy, ongole-523272

*Corresponding Author E-mail:

Online published on 18 September, 2017.

Abstract

Five series of benzothiazole moieties were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds BT-02 exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. The analgesic activity of compounds performed by using tail immersion method. in this case, compound BT-02 shows activity at 100 mg/kg dose 46 ± 0.22, 51 ± 0.22, 58 ± 0.43, 48 ± 0.27 at time interval of 30 min, 1 hour, 2 hour, 3 hour respectively compare with the other compounds due to the greater electronic effects.

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Keywords

Benzthiazole, anti microbial activity, tail immersion method.

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