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Asian Journal of Research in Pharmaceutical Science
Year : 2017, Volume : 7, Issue : 2
First page : ( 97) Last page : ( 104)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2017.00015.7

Chitosan Based Sustained Release Mucoadhesive Buccal Patches Containing Amlodipine Besylate (AMB)

Marabathuni V Jhansipriya1,*, Dinesh P.1, Ravikumar R.1, Yamini P.1, Kiran P. Sai1, Hussain Sd. P.1, Rao Ch. M.M. Prasada

1Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili

2Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole

*Corresponding Author E-mail: raj_mujoriya@live.com

Online published on 18 September, 2017.

Abstract

The buccal region of the oral cavity is an attractive target for administration of the drug of choice. Sustained release formulations have been developed and are gaining in popularity and medical acceptance. To increase bioavailability and prevent first pass metabolism of drug, Amlodipine besylate was embedded in sustained released buccal patch over period of 6 hour. The objective of present work was to characterize the effect of chitosan with PVP K-30 on water soluble drug by preparing mucoadhesive buccal patch. Each formulated batch was subjected to various evaluation parameters. The swelling percentage was found to be function of solubility of drug and PVP K-30. The mucoadhesive strength, vapour transmission and in-vitro released of water soluble drug through water insoluble chitosan base matrix were found satisfactorily. The AMB shows some suitability with those polymers.

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Keywords

Buccal Patch, Sustained Drug Delivery, Bioadhesion, Mucoadhesive Buccal Delivery.

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