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Asian Journal of Research in Pharmaceutical Science
Year : 2017, Volume : 7, Issue : 2
First page : ( 87) Last page : ( 91)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2017.00013.3

Design and Characterization of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System

Wake Prashant S.1,*, Dr. Kshirsagar M. D.2

1Research Scholar, P. Wadhwani College of Pharmacy, Yavatmal (M. S.)

2Professor, P. Wadhwani College of Pharmacy, Yavatmal (M. S.)

*Corresponding Author E-mail:

Online published on 18 September, 2017.

Abstract

Transdermal drug delivery system (TDDS) is the dosage forms which deliver a therapeutically effective amount of drug across a patient's skin. The Solid lipid nanoparticles were successfully developed for rasagiline mesylate. SLN dispersions were prepared by melt emulsification and solidification at low temperature method. Physicochemical characterization including particle size, particle size distribution, Zeta potential, scanning electron microscopy, crystallinity study by DSC were carried out. In the Transdermal Drug Delivery System, Formulations F1-F9 was prepared by solvent casting method using 1.5%, 2.5% and 3.5% of HPMC K4M and 20%, 30% and 40% (w/w of dry polymer) of PEG 400. The formulation F5 was selected as the promising formulation on the basis of tensile strength, % elongation, and % drug content. Further, the patch was found to be free of skin irritation. From the results stability study it can be concluded that the patches can be stored at 40°C and 75% RH without any significant stability problems. The formulation satisfied all the pharmaceutical parameters of transdermal films and appears to be promising.

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Keywords

Transdermal drug delivery system, Solid lipid nanoparticles, rasagiline mesylate, Physicochemical characterization, solvent casting method.

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