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Asian Journal of Research in Pharmaceutical Science
Year : 2017, Volume : 7, Issue : 1
First page : ( 49) Last page : ( 52)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2017.00008.X

Formulation Development and Optimization of Simvastatin Loaded Solid Lipid Nanoparticles

Vakhariya Rohan R.*, Talokar Swati S., Dr. Salunkhe V. R., Dr. Magdum C. S.

Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India

*Corresponding Author E-mail: rohanwakhariya@gmail.com, swatitalokar@gmail.com

Online published on 18 September, 2017.

Abstract

The present research work support preformulation, formulation, development and optimization of solid lipid nanoparticles containing simvastatin as an antihyperlipidemic drug. The different batches of formulation were obtained using simvastatin as active pharmaceutical ingredient, stearic acid as the source of lipid and β-cyclodextrin as a polymer. Solid lipid nanoparticles of simvastatin were prepared by precipitation method. The prepared formulations were evaluated for various parameters like Particle size, Percentage entrapment efficiency, Measurement of Zeta Potential, FTIR, in-vitro release study. The result was found to be within standard limit. FTIR study reports indicated that there was no interaction between Simvastatin and other excipients. Motic microscope shown that the nanoparticles size ranges from 100-550nm. Percent entrapment efficiency was between 61.40%-92.30%. Based on the resultants of the entrapment and particle size of nanoparticles, formulation S6 was observed to be optimized formulation. The optimized formulation exhibited 63.75% cumulative drug release after 24 h. The optimized batch shows mean of zeta potential at-44.0 mV.

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Keywords

Antihyperlipidemic drug, β-cyclodextrin, entrapment efficiency, Zeta Potential, Motic microscope.

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