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Asian Journal of Research in Pharmaceutical Science
Year : 2017, Volume : 7, Issue : 1
First page : ( 33) Last page : ( 37)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2017.00006.6

Gelucire: An Optional Innovative Tool for both Sustained and Fast Release of Drugs in Treating Diabetes Mellitus Type II Disease

Harikrishnan V1,*, Sreejith M2, Elthose M.J1, Marathakam Akash3

1Mookamabika College of Pharmaceutical Science and Research, Muvatupuzha Kerala, India

2Nazareth College of Pharmacy, Thiruvalla, Kerala, India

3National College of Pharmacy Kozhikode, Kozhikode, Kerala, India

*Corresponding Author E-mail: hariforjournal@gmail.com

Online published on 18 September, 2017.

Abstract

Gelucire is the group of vehicle got from blends of mono-, di-and tri-glycerides with PEG esters of unsaturated fats. They have a wide assortment of utilization in pharmaceutical definitions. These are utilized as a part of the arrangement of quick release and maintained release of drug in sustained manner. Keeping in mind the end goal to build the bioavailability of medications, the residence time of the orally controlled dose frame in the upper GIT should be drawn out. The principle ways to deal with drawing out the gastric residence time of pharmaceutical dosage form incorporates thickness control conveyance framework, which drift on gastric liquid and a resource for treat Diabetes sort II. Gastro retentive strong scattering could be accomplished of ineffectively solvent medication Glibenclamide with the assistance of polyethylene glycol and Gelucire 50/13. Then again managed discharge gastroretentive multiparticulates of metformin hydrochloride could be accomplished utilizing Gelucire 39/01 and 43/01 grades. Further both details can be investigated individual and also in mix for enhanced bioavailability by their pharmacokinetic and pharmacodynamic assessment in wistar rats.

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Keywords

Gelucire, Metformin, Glibenclamide, Solid dispersion.

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