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Asian Journal of Research in Pharmaceutical Science
Year : 2016, Volume : 6, Issue : 4
First page : ( 223) Last page : ( 229)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2016.00031.X

Formulation and Evaluation of Controlled Release Matrix Tablet of Albuterol Sulphate

Aher Smita S.1,*, Songire Poonam R.2, Saudagar Ravindra B.1

1Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, India

2Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, India

*Corresponding Author E-mail: poonamsongire1@gmail.com

Online published on 2 February, 2017.

Abstract

A sustained release matrix formulation for Albuterol Sulphate was designed and developed to achieve a 12 h release profile. Using HPMC K15M and HPMC K100M as an inert matrix forming agent to control the release of Albuterol Sulphate. The matrix tablets for these formulations were prepared by direct compression and their in-vitro release tests were carried out for a period of 12 hours using USP dissolution test apparatus (type II Paddle) at 37±0.5°C and 50 rpm speed. A 32 full factorial design was used for optimization by taking the concentration of HPMC K15M (X1) and HPMC K100M (X2) were selected as independent variables, whereas initial release at the (Y1, % drug release), (Y2, % drug Content) the concentration of Were chosen as dependent variables. The optimized formulation F9 follows Higuchi model and Korsemeyer-Pappas release kinetics with non-Fickian diffusion mechanism. From the study, it was concluded that the release of Albuterol Sulphate can be effectively controlled using combination of HPMC K15M, HPMC K 100M and Carbopol 940.

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Keywords

Albuterol Sulphate, Gelucire43/01, melt method, Direct compression method, Factorial design.

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