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Asian Journal of Research in Pharmaceutical Science
Year : 2016, Volume : 6, Issue : 3
First page : ( 185) Last page : ( 190)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2016.00025.4

Validated First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Lansoprazole and Aspirin in Tablet Dosage Forms

Kumaraswamy G.*, Lalitha Repudi, Kumar D. Sudheer

Department of Pharmaceutical Analysis, Care College of Pharmacy, Athamakur (Mdl), Oglapur(V), Warangal (Dist), Telangana

*Corresponding Author E-mail: kumaraswamy.gandla@gmail.com

Online published on 18 October, 2016.

Abstract

The present work was aimed at method development and validation for simultaneous estimation of Lansoprazole and Aspirin by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method Methanol as solvent and λmax of Lansoprazole and Aspirin were found to be 232nm and 222nm respectively. Concentration ranges were found to be 4–20μg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Lansoprazole and Aspirin respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95–105% for Lansoprazole and Aspirin. LOD and LOQ ranges were found to be 0.177 and 0.539μg/mL and 0.298 and 0.903μg/mL for Lansoprazole and Aspirin repectively. This method was validated using ICH guidelines.

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Keywords

Aspirin, Lansoprazole, UV-Spectrophotometric method, Simultaneous equation, Validation.

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