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Asian Journal of Research in Pharmaceutical Science
Year : 2016, Volume : 6, Issue : 3
First page : ( 146) Last page : ( 152)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2016.00020.5

Mucoadhesive Formulations for Buccal Mucosa

Aher Smita S.1,*, Sangale Vaishali D.1, Saudagar Ravindra B.1

1Department of Pharmaceutical Chemistry, KCT'S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, India

2Department of Quality Assurance Technique, KCT'S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, India

*Corresponding Author E-mail: smitarohokale@yahoo.com

Online published on 18 October, 2016.

Abstract

Mucoadhesion could be a field of current interest within the style of drug delivery systems. Mucoadhesive drug delivery system prolongs the continuance of the indefinite quantity kind at the positioning of application or absorption associate degreed facilitates an intimate contact of the indefinite quantity kind with the underline absorption surface and so contributes to improved and higher therapeutic performance of the drug. In recent years several such mucoadhesive drug delivery systems are developed for oral, buccal, nasal, body part and canal routes for each general and native effects.

Issues like high first-pass metabolism and drug degradation within the canal surroundings is circumvented by administering the drug via the buccal route. Moreover, speedy onset of action is achieved relative to the oral route and therefore the formulation is removed if medical care is needed to be out of print. It's additionally attainable to administer medication to patients UN agency unconscious and fewer co-operative. To forestall accidental swallowing of medicine adhesive tissue layer indefinite quantity forms were advised for oral delivery, including adhesive tablets, adhesive gels, adhesive patches and plenty of alternative indefinite quantity forms with numerous combos of polymers, absorption enhancers. Additionally to the current, studies are conducted on the event of controlled or slow unharness delivery systems for general and native medical care of diseases.

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Keywords

Buccal region, mucoadhesive, 1st pass metabolism.

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