(18.207.102.38)
Users online: 2154    [ij] [ij] [ij] 
Email id
 

Asian Journal of Research in Pharmaceutical Science
Year : 2015, Volume : 5, Issue : 4
First page : ( 227) Last page : ( 233)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2015.00033.8

Biologically Active Oxadiazole

Shukla Chhama*, Srivastav Sanchit

Noida Institute of Engineering and Technology, Gr. Noida, (UP), 201308

*Corresponding Author E-mail: chhama.shukla92@gmail.com

Online published on 29 January, 2016.

Abstract

As we know that, Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-member ring and is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogen (−N=) [1, 2]. There are three known isomers that is 1, 2, 4-oxadiazole, 1, 2, 3-oxadiazole and 1, 2, 5-oxadiazole (Figure 1.0). However, 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole are better known, and more widely studied by researchers because of their many important chemical and biological properties.

Among heterocyclic compounds, 1, 3, 4-oxadiazole has become an important construction motif for the development of new drugs. Compounds containing 1, 3, 4-oxadiazole cores have a broad biological activity spectrum including antibacterial, antifungal, analgesic, anti-inflammatory, antiviral, anticancer, antihypertensive, anticonvulsant, and anti-diabetic properties. They have also attracted interest in medicinal chemistry as surrogates (bioisosteres) for carboxylic acids, esters and carboxamides. The ability of 1, 3, 4-oxadiazole heterocyclic compounds to undergo various chemical reactions has made them important for molecule planning because of their privileged structure, which has enormous biological potential. Some examples of compounds containing the 1, 3, 4-oxadiazole unit currently used in clinical medicine are: Raltegravir as an antiretroviral drug and Zibotentan as an anticancer agent. They possesses various other biological activities and having various synthetic approaches, some of them are presented here in the article.

Top

Keywords

Oxadiazoles synthetic approaches, biologically active ozadiazoles, oxadiazoles as anticancers etc.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
452,886,534 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.