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Asian Journal of Research in Pharmaceutical Science
Year : 2015, Volume : 5, Issue : 2
First page : ( 103) Last page : ( 110)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2015.00017.X

Studies on Memory Enhancing Property of Bravobol-A Polyherbal Formulation in Experimentally Induced Alzheimers Disease in Experimental Animals

Islam Monirul1,*, Ramanjaneyulu J1, Babu D Veeresh1, Hoque Mohibul1, Swamy V.B Narayana2

1Department of Pharmacology, Karavali College of Pharmacy, Mangalore

2Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore

*Corresponding Author E-mail: moni.islam177@gmail.com

Online published on 8 December, 2015.

Abstract

In recent decades, it has become one of the principal pillars of a branch of science called cognitive neuroscience, an interdisciplinary link between cognitive and neuroscience. The objective of this to investigate the neuropsychological effect of a polyherbal formulation Bravobol on learning and memory processes in mice by elevated plus maze and Morris water maze model. Bravobol contains Evolvulus alsinoids (Shankhpushpi), Bacopa monnieri (Brahmi), Withania somnifera (Ashwagandha), Celastrus paniculatus (Malkangani) and Abhrak bhasma. Its effect (250, 500, and 750 mg/kg, p.o.) was tested on learning and memory processes. Activity of Bravobol on acquisition and retention was studied using elevated plus maze model (EPM) and spatial memory using Morris water maze model (MWM) in mice. The results were compared with the vehicle-treated group. Administration of Bravobol (250, 500 and 750 mg/kg, p.o) showed significant reduction in transfer latency in EPM and escape latency in MWM as compared to the control group. Bravobol may act as a memory enhancer formulation and may also be useful as a supportive adjuvant in the treatment of Alzheimers disease.

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Keywords

Polyherbal formulation, elevated pluz maze, Moriss water maze.

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