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Asian Journal of Research in Pharmaceutical Science
Year : 2015, Volume : 5, Issue : 1
First page : ( 55) Last page : ( 58)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2015.00009.0

Pleiotropic Effects of Statins

Gaikwad Puja S.1,*, Gadhave Dhanshri U.1, Pimpodkar Nayna V.2, Mandhare Trushali A.1

1Lecturer, College of Pharmacy (D. Pharm) Degaon, Satara, (MH), India-415 004

2Principal, College of Pharmacy (D. Pharm) Degaon, Satara, (MH), India-415 004

*Corresponding Author E-mail: pujark009@gmail.com

Online published on 8 December, 2015.

Abstract

Statins are the most commonly prescribed drugs worldwide, are cholesterol lowering agents used to manage and prevent cardiovascular and coronary heart diseases. Recently a multifaceted actions in different physiological and pathological conditions has been also proposed for statins such as antiiflammation, neuroprotection etc. Statins have been shown to act through cholesterol dependant & independent mechanisms which are able to affect several tissue functions and modulate specific signal transduction pathways. Here we review the pharmacology of statins, providing a comprehensive update of the current knowledge of their effects on tissues, biological processes & pathological conditions; but statins are now becoming recognized as powerful anti-inflammatory agents that exert beneficial effects beyond low density lipoprotein cholesterol reduction.

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