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Asian Journal of Research in Pharmaceutical Science
Year : 2015, Volume : 5, Issue : 1
First page : ( 1) Last page : ( 7)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2015.00001.6

Synthesis and Antidiabetic Activity of Novel 4-((2, 4-Dioxothiazolidin-5-ylidene)methyl)Substituted Benzene Sulphonamide

Patel Kishan D.1,*, Patel Chhaganbhai N.2, Patel Grishma M.3

1Shree S. K. Patel College of Pharmaceutical Education & Research, Gujarat, India

2Shri Sarvajanic Pharmacy College, Gujarat, India

3K. B. Institute of Pharmaceutical Education & Research, Gujarat, India

*Corresponding Author E-mail: kishan_birju@yahoo.com

Online published on 8 December, 2015.

Abstract

A new series of 4-((2, 4-dioxathiazolidin-5-ylidine)methyl)substituted benzene sulphonamide was prepared. The purity of the new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1H-NMR and mass spectroscopy. All the target compounds were evaluated for their in vivo antidiabetic activity on male Wistar rats by Oral Glucose Tolerance Test (OGTT) method using pioglitazone as standard. Amongst all, compound K17 and K18 exhibited more prominent antidiabetic activity. The results were statistically verified for its significance.

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Keywords

2, 4-dioxathiazolidin, antidiabetic, OGTT, statistically significant, spectroscopy.

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