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Asian Journal of Research in Pharmaceutical Science
Year : 2020, Volume : 10, Issue : 1
First page : ( 1) Last page : ( 5)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.
Article DOI : 10.5958/2231-5659.2020.00001.6

Formulation and Evaluation of Effervescent Floating Tablets of Domperidone

Dr Reddy Y. Krishna1, Kumar K. Satheesh1

1Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana

Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 3 June, 2020.

Abstract

The present study was undertaken to prolong the release of orally administered drug. The objective of the study was to formulate the sustained release floating tablet of Domperidone. The floating tablets of Domperidone were prepared by direct compression method. For this, polymers like HPMC K4M, Sodium CMC and Carbopol p934 were used in various concentrations. Sodium bicarbonate was used as a floating effervescent agent. The formulations were evaluated for various physical parameters, floating lag time, In-vitro drug release. From the results obtained, Formulation F9 gives desirable Sustained effect for 12 hours having 98.42% drug release at the end of the 12 hours. formulation F9 contain Carbopol p934 in concentration 2mg.

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Keywords

Domperidone, HPMC K4M, Sodium CMC and Carbopol p934, Floating Tablets.

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